With the Whites winless in their last seven in the league, only outside the relegation zone on goal difference, this is not going to be an easy task for them.
Erik Ten Hag’s side have won 11 of their last 13 games, and will go level on points with second placed Manchester City with victory tonight.
However, the hosts are going to have to cope with the absence of some key players for this match, which could give Leeds some hope.
So with that in mind, we’ve taken a look at all the latest Manchester United team news ahead of Leeds’ trip to Old Trafford, right here.
One player Manchester United will have to do without on Wednesday – and the in the reverse fixture on Sunday – for reasons not relating to fitness, is Casemiro.
The midfielder has been a lynchpin for Ten Hag’s side this season, but will miss out tonight as he begins a three-match ban after being sent off for grabbing Will Hughes’ neck the weekend win over Crystal Palace.
Eriksen is also going to be absent from the centre of the park for United this evening, having been injured in the FA Cup win over Reading at the end of January.
It has since been confirmed that the ankle injury he suffered in that match, could keep him out until the end of April, meaning this match will come way too soon for the Dane.
Another midfielder United will have to cope without on Wednesday is Scott McTominay, who is also suffering through injury.
Ten Hag has confirmed that the 26-year-old will not be available for this clash with Leeds, meaning deadline day signing Marcel Sabitzer looks set to make his full debut in the centre of the park.
The French attacker has been blighted by injury this season, and that shows no sign of changing any time soon.
Martial was not involved for United against Palace at the weekend, and Ten Hag has revealed he will not feature against Leeds either, with a date for his return to action still to be identified.
Summer signing Antony was forced off in the win over Palace on Saturday, having seemingly suffered a knock in the challenge from Jeff Schlupp that led to the scuffle that prompted Casemiro’s red card.
While the extent of the Brazilian’s injury is yet to come clear, Ten Hag admitted ahead of this game, that it will keep the 22-year-old out of action against Leeds.
Donny van de Beek
Midfielder van de Beek suffered a huge blow last month, when he suffered a knee injury in the win over Bournemouth.
It has since been confirmed he is out for the remainder of the season with that setback, so he too will be absent from proceedings on Wednesday night.
Hamstring injuries have restricted Dalot to just two appearances – both in early January – for Manchester United since the World Cup, with Aaron wan Bissaka filling in at right-back.
However, the Portuguese international was an unused substitute on Saturday, meaning he could now be available for Ten Hag to call on, should he wish to do so.